Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration

Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration

Abstract Background Matrix metalloproteinases (MMPs) play important roles in remodeling the extracellular matrix and in the pathogenesis of idiopathic pulmonary fibrosis (IPF). MMP19, which is an MMP, was significantly upregulated in hyperplastic alveolar epithelial cells in IPF lung tissues and pro...

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Bibliographic Details
Main Authors: Weiming Zhao, Lan Wang, Juntang Yang, Xinyu Chen, Xiaoshu Guo, Kai Xu, Ningdan Wang, Wenyu Zhao, Cong Xia, Hui Lian, Ivan Rosas, Guoying Yu
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell Communication and Signaling
Subjects:
MMP19
E(nd)MT
ET1
SDF1/CXCR4
Pulmonary fibrosis
Online Access:https://doi.org/10.1186/s12964-023-01040-4

Internet

https://doi.org/10.1186/s12964-023-01040-4

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