Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS)

Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS)

Summary: Background: Alzheimer's Disease, the leading cause of dementia, is over-represented in females. The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset AD and is associated with aberrant cerebrospinal fluid levels (CSF) of total tau (t-tau), phosphory...

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Bibliographic Details
Main Authors: Tyler S. Saunders, Natalie Jenkins, Kaj Blennow, Craig Ritchie, Graciela Muniz-Terrera
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:EBioMedicine
Subjects:
Cerebrospinal fluid
Alzheimer disease
Apolipoprotein E
Tau proteins
Amyloid
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422004236

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http://www.sciencedirect.com/science/article/pii/S2352396422004236

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