TgVax452, an epitope-based candidate vaccine targeting Toxoplasma gondii tachyzoite-specific SAG1-related sequence (SRS) proteins: immunoinformatics, structural simulations and experimental evidence-based approaches

TgVax452, an epitope-based candidate vaccine targeting Toxoplasma gondii tachyzoite-specific SAG1-related sequence (SRS) proteins: immunoinformatics, structural simulations and experimental evidence-based approaches

Abstract Background The highly expressed surface antigen 1 (SAG1)-related sequence (SRS) proteins of T. gondii tachyzoites, as a widespread zoonotic parasite, are critical for host cell invasion and represent promising vaccine targets. In this study, we employed a computer-aided multi-method approac...

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Bibliographic Details
Main Authors: Hamidreza Majidiani, Mohammad M. Pourseif, Bahareh Kordi, Mohammad-Reza Sadeghi, Alireza Najafi
Format: Article
Language:English
Published: BMC 2024-08-01
Series:BMC Infectious Diseases
Subjects:
Toxoplasma Gondii
SRS proteins
Dynamic simulations
Online Access:https://doi.org/10.1186/s12879-024-09807-x

Internet

https://doi.org/10.1186/s12879-024-09807-x

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