Assessment of the gene mosaicism burden in blood and its implications for immune disorders

Abstract There are increasing evidences showing the contribution of somatic genetic variants to non-cancer diseases. However, their detection using massive parallel sequencing methods still has important limitations. In addition, the relative importance and dynamics of somatic variation in healthy t...

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Bibliographic Details
Main Authors: Manuel Solís-Moruno, Anna Mensa-Vilaró, Laura Batlle-Masó, Irene Lobón, Núria Bonet, Tomàs Marquès-Bonet, Juan I. Aróstegui, Ferran Casals
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92381-y