Estrogen receptor α regulates phenotypic switching and proliferation of vascular smooth muscle cells through the NRF1-OMI-mitophagy signaling pathway under simulated microgravity

Estrogen receptor α regulates phenotypic switching and proliferation of vascular smooth muscle cells through the NRF1-OMI-mitophagy signaling pathway under simulated microgravity

Vascular remodeling during microgravity exposure results in postflight cardiovascular deconditioning and orthostatic intolerance in astronauts. To clarify the underlying mechanism, we investigated whether estrogen receptor α (ERα)-NRF1-OMI-mitophagy signaling was involved in the dedifferentiation an...

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Bibliographic Details
Main Authors: Min Jiang, Zifan Liu, Junjie Shao, Jingjing Zhou, Haiming Wang, Chao Song, Xin Li, Lin Wang, Qiang Xu, Xiaojuan Liu, Lejian Lin, Ran Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Physiology
Subjects:
microgravity
vascular smooth muscle cells
phenotypic switching
proliferation
estrogen receptor α
mitophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.1039913/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.1039913/full

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