Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea

Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea

Adeno-associated virus (AAV) is the preferred vector for gene therapy of hereditary deafness, and different viral serotypes, promoters and transduction pathways can influence the targeting of AAV to different types of cells and the expression levels of numerous exogenous genes. To determine the tran...

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Bibliographic Details
Main Authors: Xi Gu, Renjie Chai, Luo Guo, Biao Dong, Wenyan Li, Yilai Shu, Xinsheng Huang, Huawei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
adeno-associated virus vectors
gene therapy
cochlea
hair cell
supporting cell
promoter
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00008/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00008/full

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