The E3 ubiquitin-protein ligase Nedd4-2 regulates the sodium chloride cotransporter NCC but is not required for a potassium-induced reduction of NCC expression

The E3 ubiquitin-protein ligase Nedd4-2 regulates the sodium chloride cotransporter NCC but is not required for a potassium-induced reduction of NCC expression

Na+ and K+ balance is influenced by the activity of the sodium chloride cotransporter NCC in the distal convoluted tubule. NCC activity and abundance are reduced by high extracellular K+. The E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated 4–2 (Nedd4-2) has been pro...

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Bibliographic Details
Main Authors: Lena L. Rosenbaek, Federica Petrillo, Miguel X. van Bemmelen, Olivier Staub, Sathish K. Murali, Robert A. Fenton
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Physiology
Subjects:
E3 ligase
ubiquitin
ubiquitylation
co-transporter
aldosterone
potassium
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.971251/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.971251/full

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