Less Severe Polymicrobial Sepsis in Conditional <i>mgmt</i>-Deleted Mice Using LysM-Cre System, Impacts of DNA Methylation and MGMT Inhibitor in Sepsis

Less Severe Polymicrobial Sepsis in Conditional <i>mgmt</i>-Deleted Mice Using LysM-Cre System, Impacts of DNA Methylation and MGMT Inhibitor in Sepsis

The O6-methylguanine-DNA methyltransferase (MGMT) is a DNA suicide repair enzyme that might be important during sepsis but has never been explored. Then, the proteomic analysis of lipopolysaccharide (LPS)-stimulated wild-type (WT) macrophages increased proteasome proteins and reduced oxidative phosp...

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Bibliographic Details
Main Authors: Kritsanawan Sae-khow, Pornpimol Phuengmaung, Jiraphorn Issara-Amphorn, Jiradej Makjaroen, Peerapat Visitchanakun, Atsadang Boonmee, Salisa Benjaskulluecha, Tanapat Palaga, Asada Leelahavanichkul
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
sepsis
lipopolysaccharide
macrophages
epigenetics
<i>mgmt</i>
Online Access:https://www.mdpi.com/1422-0067/24/12/10175

Internet

https://www.mdpi.com/1422-0067/24/12/10175

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