Improved Biodistribution and Extended Serum Half-Life of a Bacteriophage Endolysin by Albumin Binding Domain Fusion

Improved Biodistribution and Extended Serum Half-Life of a Bacteriophage Endolysin by Albumin Binding Domain Fusion

The increasing number of multidrug-resistant bacteria intensifies the need to develop new antimicrobial agents. Endolysins are bacteriophage-derived enzymes that degrade the bacterial cell wall and hold promise as a new class of highly specific and versatile antimicrobials. One major limitation to t...

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Bibliographic Details
Main Authors: Johan Seijsing, Anna M. Sobieraj, Nadia Keller, Yang Shen, Annelies S. Zinkernagel, Martin J. Loessner, Mathias Schmelcher
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Microbiology
Subjects:
staphylococci
antibiotic alternatives
biodistribution
half-life
endolysin
albumin binding domain (ABD)
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02927/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02927/full

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