Demuxafy: improvement in droplet assignment by integrating multiple single-cell demultiplexing and doublet detection methods

Demuxafy: improvement in droplet assignment by integrating multiple single-cell demultiplexing and doublet detection methods

Abstract Recent innovations in single-cell RNA-sequencing (scRNA-seq) provide the technology to investigate biological questions at cellular resolution. Pooling cells from multiple individuals has become a common strategy, and droplets can subsequently be assigned to a specific individual by leverag...

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Bibliographic Details
Main Authors: Drew Neavin, Anne Senabouth, Himanshi Arora, Jimmy Tsz Hang Lee, Aida Ripoll-Cladellas, sc-eQTLGen Consortium, Lude Franke, Shyam Prabhakar, Chun Jimmie Ye, Davis J. McCarthy, Marta Melé, Martin Hemberg, Joseph E. Powell
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Genome Biology
Subjects:
Single-cell analysis
Genetic demultiplexing
Doublet detecting
Online Access:https://doi.org/10.1186/s13059-024-03224-8

Internet

https://doi.org/10.1186/s13059-024-03224-8

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