Chromatographic column with nitrile sorbent USED in the analysis of hydroxycarbamide by hydrophilic interaction liquid chromatography

The possibility of using chromatographic columns Zorbax SB CN 150´4,6 mm (5 μm) for separation of hydroxycarbamide (hydroxyurea) and its impurity urea has been investigated. The mixture of acetonitrile and water has been used as a mobile phase used. Separation of analytes on nitrile columns under th...

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Bibliographic Details
Main Authors: A. S. Osipov, E. B. Nechaeva, L. A. Truhacheva
Format: Article
Language:Russian
Published: Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) 2018-02-01
Series:Регуляторные исследования и экспертиза лекарственных средств
Subjects:
Online Access:https://www.vedomostincesmp.ru/jour/article/view/95