Parecoxib sodium alleviates ischemia reperfusion‐induced pulmonary injury via inhibiting ERK/NF‐κB and further activating the HIF‐1α pathway

Parecoxib sodium alleviates ischemia reperfusion‐induced pulmonary injury via inhibiting ERK/NF‐κB and further activating the HIF‐1α pathway

Abstract Introduction The lungs are extremely vulnerable to ischemia/reperfusion (I/R), which is characterized by intense inflammation, oxidative stress, alveolar damage, and vascular permeability. Parecoxib sodium (Pare) has been shown to exert protective effects against multiple I/R‐induced tissue...

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Bibliographic Details
Main Authors: Jiantao Guo, Yiping Yang
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:Immunity, Inflammation and Disease
Subjects:
hypoxia‐inducible factor‐1α
inflammatory response
ischemia reperfusion
oxidative stress
parecoxib
Online Access:https://doi.org/10.1002/iid3.684

Internet

https://doi.org/10.1002/iid3.684

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