Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase
Promoter recognition is a critical step in the initiation of transcription of DNA to RNA. Here, the authors describe a novel mechanism by which a phage-encoded RNA polymerase recognizes viral promoters containing deoxyuridines instead of thymidines.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31214-6 |
| _version_ | 1811227032917377024 |
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| author | Alec Fraser Maria L. Sokolova Arina V. Drobysheva Julia V. Gordeeva Sergei Borukhov John Jumper Konstantin V. Severinov Petr G. Leiman |
| author_facet | Alec Fraser Maria L. Sokolova Arina V. Drobysheva Julia V. Gordeeva Sergei Borukhov John Jumper Konstantin V. Severinov Petr G. Leiman |
| author_sort | Alec Fraser |
| collection | DOAJ |
| description | Promoter recognition is a critical step in the initiation of transcription of DNA to RNA. Here, the authors describe a novel mechanism by which a phage-encoded RNA polymerase recognizes viral promoters containing deoxyuridines instead of thymidines. |
| first_indexed | 2024-04-12T09:34:23Z |
| format | Article |
| id | doaj.art-721111b55e21403f9a09179504ea30f4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T09:34:23Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-721111b55e21403f9a09179504ea30f42022-12-22T03:38:16ZengNature PortfolioNature Communications2041-17232022-06-0113111810.1038/s41467-022-31214-6Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymeraseAlec Fraser0Maria L. Sokolova1Arina V. Drobysheva2Julia V. Gordeeva3Sergei Borukhov4John Jumper5Konstantin V. Severinov6Petr G. Leiman7Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical BranchDepartment of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical BranchCenter of Life Sciences, Skolkovo Institute of Science and TechnologyCenter of Life Sciences, Skolkovo Institute of Science and TechnologyDepartment of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine at StratfordDeepMind Technologies LimitedCenter of Life Sciences, Skolkovo Institute of Science and TechnologyDepartment of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical BranchPromoter recognition is a critical step in the initiation of transcription of DNA to RNA. Here, the authors describe a novel mechanism by which a phage-encoded RNA polymerase recognizes viral promoters containing deoxyuridines instead of thymidines.https://doi.org/10.1038/s41467-022-31214-6 |
| spellingShingle | Alec Fraser Maria L. Sokolova Arina V. Drobysheva Julia V. Gordeeva Sergei Borukhov John Jumper Konstantin V. Severinov Petr G. Leiman Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase Nature Communications |
| title | Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase |
| title_full | Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase |
| title_fullStr | Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase |
| title_full_unstemmed | Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase |
| title_short | Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase |
| title_sort | structural basis of template strand deoxyuridine promoter recognition by a viral rna polymerase |
| url | https://doi.org/10.1038/s41467-022-31214-6 |
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