XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMAC

XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMAC

Alcohol-associated liver disease (ALD) has been recognized as the most common cause of advanced liver disease worldwide, though mechanisms of pathogenesis remain incompletely understood. The X-linked inhibitor of apoptosis (XIAP) protein was originally described as an anti-apoptotic protein that dir...

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Bibliographic Details
Main Authors: Li He, Tejasav S. Sehrawat, Vikas K. Verma, Amaia Navarro-Corcuera, Guneet Sidhu, Amy Mauer, Xin Luo, Tomohiro Katsumi, Jingbiao Chen, Soni Shah, Juan Pablo Arab, Sheng Cao, Hamid Kashkar, Gregory J. Gores, Harmeet Malhi, Vijay H. Shah
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Physiology
Subjects:
ALD
apoptosis
scRNA sequencing
IAP
alcoholic hepatitis
alcohol-associated liver disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.664222/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.664222/full

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