Evaluation of tumor response to immune checkpoint inhibitors by a 3D immunotumoroid model

Evaluation of tumor response to immune checkpoint inhibitors by a 3D immunotumoroid model

BackgroundOnly 20 percent of renal and bladder cancer patients will show a significant response to immune checkpoint inhibitor (ICI) therapy, and no test currently available accurately predicts ICI response.MethodsWe developed an “immunotumoroid” cell model system that recapitulates the tumor, its m...

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Bibliographic Details
Main Authors: Abdulmohammad Pezeshki, John C. Cheville, Angela B. Florio, Bradley C. Leibovich, George Vasmatzis
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint inhibitor (ICI)
immunotumoroid
prediction of response to immune checkpoint inhibitor (ICI) therapy
tumor-infiltrating lymphocytes (TILs)
microcancer
patient derived tumor spheroid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1356144/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1356144/full

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