Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2

Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2

Mutations in the ubiquitin (Ub) chaperone Ubiquilin 2 (UBQLN2) cause X-linked forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) through unknown mechanisms. Here, we show that aggregation-prone, ALS-associated mutants of UBQLN2 (UBQLN2ALS) trigger heat stress-dependent ne...

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Bibliographic Details
Main Authors: Sang Hwa Kim, Kye D Nichols, Eric N Anderson, Yining Liu, Nandini Ramesh, Weiyan Jia, Connor J Kuerbis, Mark Scalf, Lloyd M Smith, Udai Bhan Pandey, Randal S Tibbetts
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-04-01
Series:eLife
Subjects:
amyotrophic lateral sclerosis
UBQLN2
axon guidance
induced motor neuron
genetic screen
protein aggregation
Online Access:https://elifesciences.org/articles/84382

Internet

https://elifesciences.org/articles/84382

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