Metabolic Modulation of Intracellular Ammonia via Intravesical Instillation of Nanoporter‐Encased Hydrogel Eradicates Bladder Carcinoma

Metabolic Modulation of Intracellular Ammonia via Intravesical Instillation of Nanoporter‐Encased Hydrogel Eradicates Bladder Carcinoma

Abstract Tumor protein 53 (TP53) mutation in bladder carcinoma (BC), upregulates the transcription of carbamoyl phosphate synthetase 1 (CPS1), to reduce intracellular ammonia toxicity. To leverage ammonia combating BC, here, an intravesically perfusable nanoporter‐encased hydrogel system is reported...

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Bibliographic Details
Main Authors: Weiqiang Jing, Chen Chen, Ganyu Wang, Maosen Han, Shouzhen Chen, Xin Jiang, Chongdeng Shi, Peng Sun, Zhenmei Yang, Benkang Shi, Xinyi Jiang
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Advanced Science
Subjects:
bladder carcinoma
carbamoyl phosphate synthetase 1
metabolic modulation
urea
urea transporter‐B
Online Access:https://doi.org/10.1002/advs.202206893

Internet

https://doi.org/10.1002/advs.202206893

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