Tackling Glaucoma from within the Brain: An Unfortunate Interplay of BDNF and TrkB.

According to the neurotrophin deprivation hypothesis, diminished retrograde delivery of neurotrophic support during an early stage of glaucoma pathogenesis is one of the main triggers that induce retinal ganglion cell (RGC) degeneration. Therefore, interfering with neurotrophic signaling seems an at...

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Bibliographic Details
Main Authors: Eline Dekeyster, Emiel Geeraerts, Tom Buyens, Chris Van den Haute, Veerle Baekelandt, Lies De Groef, Manuel Salinas-Navarro, Lieve Moons
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4641732?pdf=render