Inverted CD8 T-Cell Exhaustion and Co-Stimulation Marker Balance Differentiate Aviremic HIV-2-Infected From Seronegative Individuals

Inverted CD8 T-Cell Exhaustion and Co-Stimulation Marker Balance Differentiate Aviremic HIV-2-Infected From Seronegative Individuals

HIV-2 is less pathogenic compared to HIV-1. Still, disease progression may develop in aviremic HIV-2 infection, but the driving forces and mechanisms behind such development are unclear. Here, we aimed to reveal the immunophenotypic pattern associated with CD8 T-cell pathology in HIV-2 infection, in...

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Bibliographic Details
Main Authors: Lydia Scharf, Christina B. Pedersen, Emil Johansson, Jacob Lindman, Lars R. Olsen, Marcus Buggert, Sten Wilhelmson, Fredrik Månsson, Joakim Esbjörnsson, Antonio Biague, Patrik Medstrand, Hans Norrgren, Annika C. Karlsson, Marianne Jansson, the SWEGUB CORE Group
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
HIV-2
aviremic
CD8 T cell phenotypes
immune activation
T cell exhaustion
costimulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.744530/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.744530/full

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