TROP2 promotes PINK1-mediated mitophagy and apoptosis to accelerate the progression of senile chronic obstructive pulmonary disease by up-regulating DRP1 expression

Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease characterised by irreversible airflow limitation. The elderly are a vulnerable population for developing COPD. With the growth of age, physiological degenerative changes occur in the thorax, bronchus, lung and vasc...

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Bibliographic Details
Main Authors: Yipu Zhao, Zhengjie Wu
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Experimental Gerontology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556524000834