Amino acid-mPEGs: Promising excipients to stabilize human growth hormone against aggregation

Objective(s): Today, the non-covalent PEGylation methods of protein pharmaceuticals attract more attention and possess several advantages over the covalent approach. In the present study, Amino Acid-mPEGs (aa-mPEGs) were synthesized, and the human Growth Hormone (hGH) stability profile was assessed...

Full description

Bibliographic Details
Main Authors: Somayeh Vakili, JamshidKhan Chamani, Zeinab Amiri-Tehranizadeh, Hossein Hosseinzadeh, Fatemeh Mosaffa, Seyed-Mola Khatami, Bahman Khameneh, Mohammad Reza Saberi
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2023-06-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Online Access:https://ijbms.mums.ac.ir/article_22134_d743c8d5c5d543e0cda3f99d476beb69.pdf