Antiproliferative Activity of a New Quinazolin-4(3<i>H</i>)-One Derivative via Targeting Aurora Kinase A in Non-Small Cell Lung Cancer

Antiproliferative Activity of a New Quinazolin-4(3<i>H</i>)-One Derivative via Targeting Aurora Kinase A in Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) is the most common lung cancer subtype. Although chemotherapy and targeted therapy are used for the treatment of patients with NSCLC, the survival rate remains very low. Recent findings suggested that aurora kinase A (AKA), a cell cycle regulator, is a potential ta...

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Bibliographic Details
Main Authors: Ji Yun Lee, Huarong Yang, Donghwa Kim, Kay Zin Kyaw, Ruoci Hu, Yanhua Fan, Sang Kook Lee
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceuticals
Subjects:
non-small cell lung cancer
aurora kinase A
quinazolin-4(3<i>H</i>)-one derivative
G<sub>2</sub>/M cell cycle arrest
EGFR-TKI
combination therapy
Online Access:https://www.mdpi.com/1424-8247/15/6/698

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https://www.mdpi.com/1424-8247/15/6/698

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