Replication Activities of Major 5′ Terminally Deleted Group-B Coxsackievirus RNA Forms Decrease PCSK2 mRNA Expression Impairing Insulin Maturation in Pancreatic Beta Cells

Replication Activities of Major 5′ Terminally Deleted Group-B Coxsackievirus RNA Forms Decrease PCSK2 mRNA Expression Impairing Insulin Maturation in Pancreatic Beta Cells

Emergence of 5′ terminally deleted coxsackievirus-B RNA forms (CVB-TD) have been associated with the development of human diseases. These CVB-TD RNA forms have been detected in mouse pancreas during acute or persistent experimental infections. To date, the impact of the replication activities of CVB...

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Bibliographic Details
Main Authors: Domitille Callon, Aurélien Guedra, Anne-Laure Lebreil, Laetitia Heng, Nicole Bouland, Paul Fornès, Fatma Berri, Laurent Andreoletti
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Viruses
Subjects:
group-B coxsackievirus
pancreatitis
type 1 diabetes
5′ terminal deletion
insulin
Online Access:https://www.mdpi.com/1999-4915/14/12/2781

Internet

https://www.mdpi.com/1999-4915/14/12/2781

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