Protective Effect of 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione, Isolated from Averrhoa Carambola L., Against Palmitic Acid-Induced Inflammation and Apoptosis in Min6 Cells by Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway

Protective Effect of 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione, Isolated from Averrhoa Carambola L., Against Palmitic Acid-Induced Inflammation and Apoptosis in Min6 Cells by Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway

Background/Aims: Studies have demonstrated that 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione (DMDD), isolated from the roots of Averrhoa carambola L., has significant therapeutic potential for the treatment of diabetes. However, the protective effect of DMDD against pancreatic beta cell dysfun...

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Bibliographic Details
Main Authors: Qiuqiao Xie, Shijun Zhang, Chunxia Chen, Juman Li, Xiaojie Wei, Xiaohui Xu, Feifei Xuan, Ning Chen, Thithaihoa Pham, Ni Qin, Junhui He, Fangxing Ye, Wansu Huang, Renbin Huang, Qingwei Wen
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
MyD88
DMDD
Inflammation
Apoptosis
TLR4
NF-κB
Min6 cell
Online Access:http://www.karger.com/Article/FullText/447871

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http://www.karger.com/Article/FullText/447871

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