Cytoplasmic polyadenylation by TENT5A is required for proper bone formation

Cytoplasmic polyadenylation by TENT5A is required for proper bone formation

Summary: Osteoblasts orchestrate bone formation through the secretion of type I collagen and other constituents of the matrix on which hydroxyapatite crystals mineralize. Here, we show that TENT5A, whose mutations were found in congenital bone disease osteogenesis imperfecta patients, is a cytoplasm...

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Bibliographic Details
Main Authors: Olga Gewartowska, Goretti Aranaz-Novaliches, Paweł S. Krawczyk, Seweryn Mroczek, Monika Kusio-Kobiałka, Bartosz Tarkowski, Frantisek Spoutil, Oldrich Benada, Olga Kofroňová, Piotr Szwedziak, Dominik Cysewski, Jakub Gruchota, Marcin Szpila, Aleksander Chlebowski, Radislav Sedlacek, Jan Prochazka, Andrzej Dziembowski
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
TENT5A
FAM46A
osteogenesis
osteogenesis imperfecta
polyadenylation
osteoblasts
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003296

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http://www.sciencedirect.com/science/article/pii/S2211124721003296

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