Alteration in the sensitivity to crizotinib by Na+/H+ exchanger regulatory factor 1 is dependent to its subcellular localization in ALK-positive lung cancers

Alteration in the sensitivity to crizotinib by Na+/H+ exchanger regulatory factor 1 is dependent to its subcellular localization in ALK-positive lung cancers

Abstract Background Na+/H+ exchanger regulatory factor 1 (NHERF1) is an important scaffold protein participates in the modulation of a variety of intracellular signal pathways. NHERF1 was able to enhance the effects of chemo-drugs in breast and cervical cancer cells. Anaplastic lymphoma kinase (ALK)...

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Bibliographic Details
Main Authors: Fenglian Yang, Mu Hu, Siyuan Chang, Jing Huang, Yang Si, Jinghui Wang, Shan Cheng, Wen G. Jiang
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Cancer
Subjects:
NHERF1
Crizotinib
ALK
Lung cancer
PDZ protein
Online Access:http://link.springer.com/article/10.1186/s12885-020-6687-9

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http://link.springer.com/article/10.1186/s12885-020-6687-9

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