Artesunate Activates the Intrinsic Apoptosis of HCT116 Cells through the Suppression of Fatty Acid Synthesis and the NF-κB Pathway

Artesunate Activates the Intrinsic Apoptosis of HCT116 Cells through the Suppression of Fatty Acid Synthesis and the NF-κB Pathway

The artemisinin compounds, which are well-known for their potent therapeutic antimalarial activity, possess in vivo and in vitro antitumor effects. Although the anticancer effect of artemisinin compounds has been extensively reported, the precise mechanisms underlying its cytotoxicity remain under i...

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Bibliographic Details
Main Authors: Xiao Chen, Yin Kwan Wong, Teck Kwang Lim, Wei Hou Lim, Qingsong Lin, Jigang Wang, Zichun Hua
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Molecules
Subjects:
artesunate
fatty acid biosynthesis
HCT116
mitochondrial apoptosis
NF-κB pathway
proteomic analysis
Online Access:https://www.mdpi.com/1420-3049/22/8/1272

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https://www.mdpi.com/1420-3049/22/8/1272

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