Smac-mimetics reduce numbers and viability of human osteoclasts

Smac-mimetics reduce numbers and viability of human osteoclasts

Abstract Elevated activity of bone-degrading osteoclasts (OC) contributes to pathological bone degradation in diseases such as multiple myeloma. Several proinflammatory cytokines, including TNF, contribute to osteoclastogenesis. The receptor-interacting protein kinase 1 (RIPK1) regulates inflammatio...

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Bibliographic Details
Main Authors: Ingrid Nyhus Moen, Marita Westhrin, Erling Håland, Markus Haug, Unni Nonstad, Merisa Klaharn, Therese Standal, Kristian K. Starheim
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00415-1

Internet

https://doi.org/10.1038/s41420-021-00415-1

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