Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation

Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation

Abstract Background Traumatic brain injury (TBI) causes significant blood-brain barrier (BBB) breakdown, resulting in the extravasation of blood proteins into the brain. The impact of blood proteins, especially fibrinogen, on inflammation and neurodegeneration post-TBI is not fully understood, highl...

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Bibliographic Details
Main Authors: Terry Dean, Andrew S. Mendiola, Zhaoqi Yan, Rosa Meza-Acevedo, Belinda Cabriga, Katerina Akassoglou, Jae Kyu Ryu
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-024-03092-w

Internet

https://doi.org/10.1186/s12974-024-03092-w

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