Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

Abstract Background Increased transcription of the human endogenous retrovirus group HERV-K (HML-2) is often seen during disease. Although the mechanism of its tissue-specific activation is unclear, research shows that LTR CpG hypomethylation alone is not sufficient to induce its promoter activity a...

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Bibliographic Details
Main Authors: Meagan Montesion, Zachary H. Williams, Ravi P. Subramanian, Charlotte Kuperwasser, John M. Coffin
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Retrovirology
Subjects:
Endogenous retrovirus
HERV-K
HML-2
LTR
Transcription
Tumorigenesis
Online Access:http://link.springer.com/article/10.1186/s12977-018-0441-2

Internet

http://link.springer.com/article/10.1186/s12977-018-0441-2

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