4-Methylumbelliferone enhances the effects of chemotherapy on both temozolomide-sensitive and resistant glioblastoma cells

Abstract Glioblastoma (GBM) is the most frequent malignant primary tumor of the CNS in adults, with a median survival of 14.6 months after diagnosis. The effectiveness of GBM therapies remains poor, highlighting the need for new therapeutic alternatives. In this work, we evaluated the effect of 4-me...

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Bibliographic Details
Main Authors: Matías A. Pibuel, Daniela Poodts, Sofía A. Sias, Agustín Byrne, Silvia E. Hajos, Paula G. Franco, Silvina L. Lompardía
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35045-3