BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosis

BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosis

Abstract Neuroinflammation in the central nervous system (CNS), driven largely by resident phagocytes, has been proposed as a significant contributor to disability accumulation in multiple sclerosis (MS) but has not been addressed therapeutically. Bruton’s tyrosine kinase (BTK) is expressed in both...

Full description

Bibliographic Details
Main Authors: Ross C. Gruber, Gregory S. Wirak, Anna S. Blazier, Lan Lee, Michael R. Dufault, Nellwyn Hagan, Nathalie Chretien, Michael LaMorte, Timothy R. Hammond, Agnes Cheong, Sean K. Ryan, Andrew Macklin, Mindy Zhang, Nilesh Pande, Evis Havari, Timothy J. Turner, Anthony Chomyk, Emilie Christie, Bruce D. Trapp, Dimitry Ofengeim
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54430-8

Internet

https://doi.org/10.1038/s41467-024-54430-8

Similar Items