Dual reporter genetic mouse models of pancreatic cancer identify an epithelial‐to‐mesenchymal transition‐independent metastasis program

Dual reporter genetic mouse models of pancreatic cancer identify an epithelial‐to‐mesenchymal transition‐independent metastasis program

Abstract Epithelial‐to‐mesenchymal transition (EMT) is a recognized eukaryotic cell differentiation program that is also observed in association with invasive tumors. Partial EMT program in carcinomas imparts cancer cells with mesenchymal‐like features and is proposed as essential for metastasis. Pr...

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Bibliographic Details
Main Authors: Yang Chen, Valerie S LeBleu, Julienne L Carstens, Hikaru Sugimoto, Xiaofeng Zheng, Shruti Malasi, Dieter Saur, Raghu Kalluri
Format: Article
Language:English
Published: Springer Nature 2018-10-01
Series:EMBO Molecular Medicine
Subjects:
dual‐recombinase system
metastasis
micrometastasis
pancreatic ductal adenocarcinoma
partial epithelial‐to‐mesenchymal transition
Online Access:https://doi.org/10.15252/emmm.201809085

Internet

https://doi.org/10.15252/emmm.201809085

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