BMI1 induces ubiquitination and protein degradation of Nod‐like receptor family CARD domain containing 5 and suppresses human leukocyte antigen class I expression to induce immune escape in non‐small cell lung cancer

BMI1 induces ubiquitination and protein degradation of Nod‐like receptor family CARD domain containing 5 and suppresses human leukocyte antigen class I expression to induce immune escape in non‐small cell lung cancer

Abstract The Nod‐like receptor (NLR) family CARD domain containing 5 (NLRC5) has been reported as an activator of human leukocyte antigen (HLA) class I that is responsible for immune activity in cancer treatment. This work focuses on the role of BMI1 proto‐oncogene (BMI1) in the NLRC5‐HLA class I ax...

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Bibliographic Details
Main Authors: Zhi‐Hui Lu, Gan‐Jie Tu, Si‐Lv Fu, Kai Shang, Su‐Juan Peng, Li Chen, Xi‐Juan Gu
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
BMI1
HLA class I
NLRC5
PD‐1/PD‐L1
T cells
Online Access:https://doi.org/10.1002/kjm2.12602

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