Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis

Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis

Abstract Background Pancreatic cancer is one of the most lethal cancers worldwide. The IAPs function as E3 ubiquitin ligases and contribute to pancreatic cancer initiation, progression, and metastasis. Although IAP-targeted therapies have been developed and shown anticancer efficacy in preclinical s...

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Bibliographic Details
Main Authors: Simin Qi, Xiaoqing Guan, Jia Zhang, Dehua Yu, Xuefei Yu, Qinglin Li, Wenjuan Yin, Xiang-Dong Cheng, Weidong Zhang, Jiang-Jiang Qin
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Molecular Cancer
Subjects:
IAP
UbcH5c
Pancreatic cancer
Small-molecule inhibitor
NF-κB
Online Access:https://doi.org/10.1186/s12943-022-01538-4

Internet

https://doi.org/10.1186/s12943-022-01538-4

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