Punicalagin Protects Human Retinal Pigment Epithelium Cells from Ultraviolet Radiation-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway and Reducing Apoptosis

Punicalagin Protects Human Retinal Pigment Epithelium Cells from Ultraviolet Radiation-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway and Reducing Apoptosis

The oxidative damage of the retinal pigment epithelium (RPE) is the early event that underlies the pathogenesis of maculopathies. Numerous studies have shown that punicalagin (PUN), a polyphenol present in pomegranate, can protect several cell types from oxidative stress. Our study aims to establish...

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Bibliographic Details
Main Authors: Maria Elisabetta Clementi, Beatrice Sampaolese, Francesca Sciandra, Giuseppe Tringali
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Antioxidants
Subjects:
punicalagin
ARPE-19 (human-RPE cell line)
nuclear factor erythroid 2-related factor (Nrf2)
heme oxygenase-1 (HO-1)
NADPH quinone dehydrogenase-1 (NQO1)
apoptosis
Online Access:https://www.mdpi.com/2076-3921/9/6/473

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https://www.mdpi.com/2076-3921/9/6/473

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