cyy-287, a novel pyrimidine-2,4-diamine derivative, inhibits tumor growth of EGFR-driven non-small cell lung cancer via the ERK pathway

cyy-287, a novel pyrimidine-2,4-diamine derivative, inhibits tumor growth of EGFR-driven non-small cell lung cancer via the ERK pathway

In recent decades, EGFR-targeted tyrosine kinase inhibitors (TKIs) have been proven to be an effective therapy for EGFR-mutant non-small cell lung cancer (NSCLC). However, resistance to EGFR-TKIs limits their clinical application. In the present study, we investigate the antitumor effect and underly...

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Bibliographic Details
Main Authors: Zhang Qianwen, Huang Huijing, Zheng Shuwen, Tang Yelin, Zhang Xiaodan, Zhu Qianqian, Ni Zefeng, Zheng Xiaohui, Wang Kun, Huang Lehao, Zhao Yunjie, Liu Zhiguo, Qian Jianchang
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-10-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
cyy-287
non-small cell lung cancer
EGFR
ERK
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022139

Internet

https://www.sciengine.com/doi/10.3724/abbs.2022139

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