cyy-287, a novel pyrimidine-2,4-diamine derivative, inhibits tumor growth of EGFR-driven non-small cell lung cancer via the ERK pathway
In recent decades, EGFR-targeted tyrosine kinase inhibitors (TKIs) have been proven to be an effective therapy for EGFR-mutant non-small cell lung cancer (NSCLC). However, resistance to EGFR-TKIs limits their clinical application. In the present study, we investigate the antitumor effect and underly...
Main Authors: | Zhang Qianwen, Huang Huijing, Zheng Shuwen, Tang Yelin, Zhang Xiaodan, Zhu Qianqian, Ni Zefeng, Zheng Xiaohui, Wang Kun, Huang Lehao, Zhao Yunjie, Liu Zhiguo, Qian Jianchang |
---|---|
Format: | Article |
Language: | English |
Published: |
China Science Publishing & Media Ltd.
2022-10-01
|
Series: | Acta Biochimica et Biophysica Sinica |
Subjects: | |
Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2022139 |
Similar Items
-
Cyy-287, a novel pyrimidine-2,4-diamine derivative, efficiently mitigates inflammatory responses, fibrosis, and lipid synthesis in obesity-induced cardiac and hepatic dysfunction
by: Jinhuan Ni, et al.
Published: (2024-02-01) -
Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1
by: Huaping Chen, et al.
Published: (2020-11-01) -
SP.287 / 5.S15 / ESG.SP287 Kitchen Chemistry, Spring 2006
by: Christie, Patricia Dianne, 1967-
Published: (2006) -
The Unique Blazar OJ 287 and Its Massive Binary Black Hole Central Engine
by: Lankeswar Dey, et al.
Published: (2019-05-01) -
Scentless Plant Bugs, Jadera sp. (Insecta: Hemiptera: Rhopalidae)
by: Frank W. Mead, et al.
Published: (2002-11-01)