Design, Synthesis and Mechanistic Studies of Novel Isatin-Pyrazole Hydrazone Conjugates as Selective and Potent Bacterial MetAP Inhibitors

Design, Synthesis and Mechanistic Studies of Novel Isatin-Pyrazole Hydrazone Conjugates as Selective and Potent Bacterial MetAP Inhibitors

Methionine aminopeptidases (MetAPs) are attractive drug targets due to their essential role in eukaryotes as well as prokaryotic cells. In this study, biochemical assays were performed on newly synthesized Isatin-pyrazole hydrazones (<b>PS1–14</b>) to identify potent and selective bacter...

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Bibliographic Details
Main Authors: Iram Irfan, Asghar Ali, Bharati Reddi, Mohd. Abrar Khan, Phool Hasan, Sarfraz Ahmed, Amad Uddin, Magdalena Piatek, Kevin Kavanagh, Qazi Mohd. Rizwanul Haque, Shailja Singh, Anthony Addlagatta, Mohammad Abid
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antibiotics
Subjects:
Isatin-pyrazole hydrazone
ESKAPE
antibacterial
MDR
cytotoxicity
MetAP
Online Access:https://www.mdpi.com/2079-6382/11/8/1126

Internet

https://www.mdpi.com/2079-6382/11/8/1126

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