Biological and Clinicopathological Significance of Cripto-1 Expression in the Progression of Human ESCC
Background: Human Cripto-1, a member of the EGF-CFC family, is involved in embryonic development, embryonic stem cell maintenance, and tumor progression. It also participates in multiple cell signaling pathways including Wnt, Notch, and TGF-β. Remarkably, it is expressed in cancer stem cell (CSC) co...
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| Format: | Article |
| Language: | English |
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Varastegan Institute for Medical Sciences
2017-05-01
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| Series: | Reports of Biochemistry and Molecular Biology |
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| Online Access: | http://rbmb.net/article-1-106-en.pdf |
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| author | Reihaneh Alsadat Mahmoudian Mohammad Reza Abbaszadegan Mohammad Mahdi Forghanifard Meysam Moghbeli Faezeh Moghbeli Jamshidkhan Chamani Mehran Gholamin |
| author_facet | Reihaneh Alsadat Mahmoudian Mohammad Reza Abbaszadegan Mohammad Mahdi Forghanifard Meysam Moghbeli Faezeh Moghbeli Jamshidkhan Chamani Mehran Gholamin |
| author_sort | Reihaneh Alsadat Mahmoudian |
| collection | DOAJ |
| description | Background: Human Cripto-1, a member of the EGF-CFC family, is involved in embryonic development, embryonic stem cell maintenance, and tumor progression. It also participates in multiple cell signaling pathways including Wnt, Notch, and TGF-β. Remarkably, it is expressed in cancer stem cell (CSC) compartments, boosting tumor cell migration, invasion, and angiogenesis. Although Cripto-1 is overexpressed in a variety of human malignant tumors, its expression in esophageal squamous cell carcinoma (ESCC) remains unclear. Our aim in this study was to evaluate the possible oncogenic role of Cripto-1 in ESCC progression and elucidate its association with clinicopathological parameters in patients.
Methods: In this study, Cripto-1 expression in 50 ESCC tissue samples was analyzed and compared to corresponding margin-normal esophageal tissues using quantitative real-time PCR.
Results: Cripto-1 was overexpressed in nearly 40% of ESCC samples compared with normal tissue samples. Significant correlations were observed between Cripto-1 expression and tumor differentiation grade, progression stage, and location (p < 0.05).
Conclusions: Our results indicate that overexpression of Cripto-1 is involved in the development of ESCC. Further assessment will be necessary to determine the role of Cripto-1 cross talk in ESCC tumorigenesis |
| first_indexed | 2024-04-12T02:42:09Z |
| format | Article |
| id | doaj.art-7257d3685a26447d85cd6fa6e2e9c1cb |
| institution | Directory Open Access Journal |
| issn | 2322-3480 2322-3480 |
| language | English |
| last_indexed | 2024-04-12T02:42:09Z |
| publishDate | 2017-05-01 |
| publisher | Varastegan Institute for Medical Sciences |
| record_format | Article |
| series | Reports of Biochemistry and Molecular Biology |
| spelling | doaj.art-7257d3685a26447d85cd6fa6e2e9c1cb2022-12-22T03:51:18ZengVarastegan Institute for Medical SciencesReports of Biochemistry and Molecular Biology2322-34802322-34802017-05-01528390Biological and Clinicopathological Significance of Cripto-1 Expression in the Progression of Human ESCCReihaneh Alsadat Mahmoudian0Mohammad Reza Abbaszadegan1Mohammad Mahdi Forghanifard2Meysam Moghbeli3Faezeh Moghbeli4Jamshidkhan Chamani5Mehran Gholamin6Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, IranDivision of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran - Medical Genetics Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, IranDepartment Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.Faculty of Sciences, Department of Biochemistry and Biophysics, Mashhad Branch, Islamic Azad University, Mashhad, IranImmunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, IranBackground: Human Cripto-1, a member of the EGF-CFC family, is involved in embryonic development, embryonic stem cell maintenance, and tumor progression. It also participates in multiple cell signaling pathways including Wnt, Notch, and TGF-β. Remarkably, it is expressed in cancer stem cell (CSC) compartments, boosting tumor cell migration, invasion, and angiogenesis. Although Cripto-1 is overexpressed in a variety of human malignant tumors, its expression in esophageal squamous cell carcinoma (ESCC) remains unclear. Our aim in this study was to evaluate the possible oncogenic role of Cripto-1 in ESCC progression and elucidate its association with clinicopathological parameters in patients. Methods: In this study, Cripto-1 expression in 50 ESCC tissue samples was analyzed and compared to corresponding margin-normal esophageal tissues using quantitative real-time PCR. Results: Cripto-1 was overexpressed in nearly 40% of ESCC samples compared with normal tissue samples. Significant correlations were observed between Cripto-1 expression and tumor differentiation grade, progression stage, and location (p < 0.05). Conclusions: Our results indicate that overexpression of Cripto-1 is involved in the development of ESCC. Further assessment will be necessary to determine the role of Cripto-1 cross talk in ESCC tumorigenesishttp://rbmb.net/article-1-106-en.pdfCancer stem cellCripto-1ESCCExpressional analysisReal-time PCR |
| spellingShingle | Reihaneh Alsadat Mahmoudian Mohammad Reza Abbaszadegan Mohammad Mahdi Forghanifard Meysam Moghbeli Faezeh Moghbeli Jamshidkhan Chamani Mehran Gholamin Biological and Clinicopathological Significance of Cripto-1 Expression in the Progression of Human ESCC Reports of Biochemistry and Molecular Biology Cancer stem cell Cripto-1 ESCC Expressional analysis Real-time PCR |
| title | Biological and Clinicopathological Significance of Cripto-1 Expression in the Progression of Human ESCC |
| title_full | Biological and Clinicopathological Significance of Cripto-1 Expression in the Progression of Human ESCC |
| title_fullStr | Biological and Clinicopathological Significance of Cripto-1 Expression in the Progression of Human ESCC |
| title_full_unstemmed | Biological and Clinicopathological Significance of Cripto-1 Expression in the Progression of Human ESCC |
| title_short | Biological and Clinicopathological Significance of Cripto-1 Expression in the Progression of Human ESCC |
| title_sort | biological and clinicopathological significance of cripto 1 expression in the progression of human escc |
| topic | Cancer stem cell Cripto-1 ESCC Expressional analysis Real-time PCR |
| url | http://rbmb.net/article-1-106-en.pdf |
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