BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

Abstract Background β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patients. Our previous studies have shown that the clathrin adaptor Golgi-lo...

Full description

Bibliographic Details
Main Authors: WonHee Kim, Liang Ma, Selene Lomoio, Rachel Willen, Sylvia Lombardo, Jinghui Dong, Philip G. Haydon, Giuseppina Tesco
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer disease
Amyloid-beta (Aβ)
Beta-secretase 1 (BACE1)
Golgi-localized γ-ear-containing ARF binding protein 3 (GGA3)
Amyloid precursor protein (APP)
Cell adhesion molecule L1 like protein (CHL1)
Online Access:http://link.springer.com/article/10.1186/s13024-018-0239-7

Internet

http://link.springer.com/article/10.1186/s13024-018-0239-7

Similar Items