Differential roles of prostaglandin E2 EP4 receptor on stromal cell populations for hematopoietic stem and progenitor cell function

Differential roles of prostaglandin E2 EP4 receptor on stromal cell populations for hematopoietic stem and progenitor cell function

Prostaglandin E2 (PGE2) signaling through its EP4 receptor regulates hematopoietic stem and progenitor cell (HSPC) functions. Here we generated mouse strains with conditional and inducible deletion of EP4 in stromal cell populations, including osteolineage cells, mesenchymal progenitor cells, periva...

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Bibliographic Details
Main Authors: Liqiong Liu, Hongge Li, Pratibha Singh, Jonathan Hoggatt, Louis M. Pelus
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Hematology
Subjects:
prostaglandin E2 EP4 receptor
hematopoietic stem cells (HSCs)
colony forming cells (CFCs)
bone marrow transplant
peripheral blood hematopoietic cell mobilization
Online Access:https://www.frontiersin.org/articles/10.3389/frhem.2023.1292651/full

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https://www.frontiersin.org/articles/10.3389/frhem.2023.1292651/full

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