C-11, a New Antiepileptic Drug Candidate: Evaluation of the Physicochemical Properties and Impact on the Protective Action of Selected Antiepileptic Drugs in the Mouse Maximal Electroshock-Induced Seizure Model

C-11, a New Antiepileptic Drug Candidate: Evaluation of the Physicochemical Properties and Impact on the Protective Action of Selected Antiepileptic Drugs in the Mouse Maximal Electroshock-Induced Seizure Model

C-11 is a hybrid compound derived from 2-(2,5-dioxopyrrolidin-1-yl) propanamide, with a wide spectrum of anticonvulsant activity and low neurotoxicity. The aim of this study was to determine the effects of C-11 on the protective action of various antiepileptic drugs (i.e., carbamazepine CBZ, lacosam...

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Bibliographic Details
Main Authors: Mirosław Zagaja, Aleksandra Szewczyk, Joanna Szala-Rycaj, Grzegorz Raszewski, Magdalena Chrościńska-Krawczyk, Michał Abram, Krzysztof Kamiński, Marta Andres-Mach
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
antiepileptic drugs
maximal electroshock-induced seizures
pharmacokinetic/pharmacodynamic interaction
neuroprotection
physicochemical descriptors
Online Access:https://www.mdpi.com/1420-3049/26/11/3144

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https://www.mdpi.com/1420-3049/26/11/3144

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