RESISTANCE TO TARGETED THERAPIES IN MELANOMA: NEW INSIGHTS

RESISTANCE TO TARGETED THERAPIES IN MELANOMA: NEW INSIGHTS

Several molecular mechanisms are involved in melanoma genesis and progression. Molecular targets for effective therapeutic intervention have been identified within the RAS-RAF-MEK-ERK and, to a less extent, PI3K-AKT pathways. The development of inhibitors of key effectors (mainly BRAF mutant, MEK,...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Giuseppe Palmieri, Maria Colombino, Maria Cristina Sini, Antonella Manca, Paolo Antonio Ascierto, Antonio Cossu
Format: Artikel
Sprache:English
Veröffentlicht: European Medical Journal 2013-12-01
Schriftenreihe:European Medical Journal Dermatology
Schlagworte:
malignant melanoma
molecular pathogenesis
targeted therapy
braf/mek/kit inhibitors
drug resistance
Online Zugang:https://emj.emg-health.com/wp-content/uploads/sites/2/2013/12/Resistance-to-Targeted-Therapies-in-Melanoma-New-Insights.pdf

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https://emj.emg-health.com/wp-content/uploads/sites/2/2013/12/Resistance-to-Targeted-Therapies-in-Melanoma-New-Insights.pdf

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