EPR Investigations to Study the Impact of Mito-Metformin on the Mitochondrial Function of Prostate Cancer Cells

EPR Investigations to Study the Impact of Mito-Metformin on the Mitochondrial Function of Prostate Cancer Cells

Background: Mito-metformin10 (MM10), synthesized by attaching a triphenylphosphonium cationic moiety via a 10-carbon aliphatic side chain to metformin, is a mitochondria-targeted analog of metformin that was recently demonstrated to alter mitochondrial function and proliferation in pancreatic ductal...

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Bibliographic Details
Main Authors: Donatienne d’Hose, Barbara Mathieu, Lionel Mignion, Micael Hardy, Olivier Ouari, Bénédicte F. Jordan, Pierre Sonveaux, Bernard Gallez
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
EPR
ESR
tumor oxygenation
tumor hypoxia
oxygen consumption
mitochondrial ROS
Online Access:https://www.mdpi.com/1420-3049/27/18/5872

Internet

https://www.mdpi.com/1420-3049/27/18/5872

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