Venetoclax and alvocidib are both cytotoxic to acute myeloid leukemia cells resistant to cytarabine and clofarabine

Venetoclax and alvocidib are both cytotoxic to acute myeloid leukemia cells resistant to cytarabine and clofarabine

Abstract Background Cytarabine (ara-C) is the major drug for the treatment of acute myeloid leukemia (AML), but cellular resistance to ara-C is a major obstacle to therapeutic success. The present study examined enhanced anti-apoptosis identified in 3 newly established nucleoside analogue-resistant...

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Bibliographic Details
Main Authors: Rie Nishi, Hiroko Shigemi, Eiju Negoro, Miyuki Okura, Naoko Hosono, Takahiro Yamauchi
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Cancer
Subjects:
Venetoclax
Bcl-2
Alvocidib
Mcl-1
Cytarabine (ara-C)
Clofarabine (CAFdA)
Online Access:http://link.springer.com/article/10.1186/s12885-020-07469-x

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http://link.springer.com/article/10.1186/s12885-020-07469-x

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