Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer’s disease

Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer’s disease

Abstract Alzheimer's disease is associated with various brain dysfunctions, including memory impairment, neuronal loss, astrocyte activation, amyloid-β plaques, and neurofibrillary tangles. Transgenic animal models of Alzheimer's disease have proven to be invaluable for the basic research...

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Bibliographic Details
Main Authors: Sung Hyun Tag, Baeksun Kim, Jinhee Bae, Keun-A Chang, Heh-In Im
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Molecular Brain
Subjects:
6xTg
Alzheimer's disease
Cognitive impairment
Social behavior
Anxiety
Depression
Online Access:https://doi.org/10.1186/s13041-022-00933-8

Internet

https://doi.org/10.1186/s13041-022-00933-8

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