Bioinformatic Analyses and Experimental Verification Reveal that High FSTL3 Expression Promotes EMT via Fibronectin-1/α5β1 Interaction in Colorectal Cancer

Bioinformatic Analyses and Experimental Verification Reveal that High FSTL3 Expression Promotes EMT via Fibronectin-1/α5β1 Interaction in Colorectal Cancer

Background: Colorectal cancer (CRC) is a typical cancer prevalent worldwide. Despite the conventional treatments, CRC has a poor prognosis due to relapse and metastasis. Moreover, there is a dearth of sensitive biomarkers for predicting prognosis in CRC.Methods: This study used a bioinformatics appr...

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Bibliographic Details
Main Authors: Yuanjie Liu, Jiepin Li, Shuhong Zeng, Ying Zhang, Yonghua Zhang, Zhichao Jin, Shenlin Liu, Xi Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
colorecal cancer
FSTL3 gene
EMT—epithelial to mesenchymal transformation
FN1
fibronectin 1
α5β1 integrin
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.762924/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.762924/full

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