Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces neutralizing salivary IgA

Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces neutralizing salivary IgA

Intramuscularly administered vaccines stimulate robust serum neutralizing antibodies, yet they are often less competent in eliciting sustainable “sterilizing immunity” at the mucosal level. Our study uncovers a strong temporary neutralizing mucosal component of immunity, emanating from intramuscular...

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Bibliographic Details
Main Authors: Miri Stolovich-Rain, Sujata Kumari, Ahuva Friedman, Saveliy Kirillov, Yakov Socol, Maria Billan, Ritesh Ranjan Pal, Kathakali Das, Peretz Golding, Esther Oiknine-Djian, Salim Sirhan, Michal Bejerano Sagie, Einav Cohen-Kfir, Naama Gold, Jamal Fahoum, Manoj Kumar, Maya Elgrably-Weiss, Bing Zhou, Miriam Ravins, Yair E. Gatt, Saurabh Bhattacharya, Orly Zelig, Reuven Wiener, Dana G. Wolf, Hila Elinav, Jacob Strahilevitz, Dan Padawer, Leah Baraz, Alexander Rouvinski
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
secretory IgA
mucosal immunity
secretory component
BNT162b2 vaccine
SARS-CoV-2 neutralizing Abs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.933347/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.933347/full

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