Dapagliflozin impedes endothelial cell senescence by activating the SIRT1 signaling pathway in type 2 diabetes

Dapagliflozin impedes endothelial cell senescence by activating the SIRT1 signaling pathway in type 2 diabetes

Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) clinically reduce atherosclerosis and lower blood pressure. However, their impact on endothelial dysfunction in type 2 diabetes (T2D) remains unclear. In this study, we investigated the protective effect and underlying mechanism of the S...

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Bibliographic Details
Main Authors: Shi Tai, Ying Zhou, Liyao Fu, Huiqing Ding, Yuying Zhou, Zhiyi Yin, Rukai Yang, Zhenjiang Liu, Shenghua Zhou
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Heliyon
Subjects:
Diabetes
Endothelial cells
Senescence
Dapagliflozin
SGLT2 inhibitor
SIRT1
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023063600

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http://www.sciencedirect.com/science/article/pii/S2405844023063600

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